Good questions! One of the big things for me was reworking the "reason" I want to go to med school. Initially I was trying to sell myself on having done research and science is really great and all that crap. I had national average scores for matriculated students so numbers didn't kill me. But for me, I realized I didn't really like research all that much and was trying to sell a version of myself that wasn't what I really wanted (not sure if that makes sense or not). Anyways, I realized I wanted to medicine to work with patients and at the core of that was a dedication to service. So I reaffirmed that by doing two years of AmeriCorps. This allowed me to put together a really strong application that brought together my activities along with my reason for going into med school that I could sell in a more honest and unique way that when I was just out of college.
That was some A+ rambling so, tl;dr, do some reflection --> find out what you need to do to make yourself a better person and stronger applicant --> do that --> go to med school --> go into a **** load of debt --> be a doctor -->>>>>>>>>>>>>> retire happy